Reviewed by: David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc. David B. Merrill, MD, Assistant Clinical Professor of Psychiatry, Department of Psychiatry, Columbia University Medical Center, New York, NY., Our site: http://edaqmaui.vacau.com#82168 - Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the products and services advertised., Visit This Link: http://ivojruin.comeze.com#61615 - Dehydroepiandrosterone (DHEA), a metabolic precursor for several hormones including estrogen and testosterone, has been promoted as a remedy for many ailments. Sold in the 1970s and 1980s as a weight-loss aid, it was subsequently banned for over-the-counter sale in the US, but then unbanned, and is currently available as a supplement. Very few clinical trials of DHEA in depression have been performed but, in a 2010 review, Nicole Maninger and colleagues reported that "to date, every controlled trial of DHEA in depression has reported significant antidepressant effects. Although these data are encouraging, more large-scale studies will be required to establish the place, if any, of DHEA in the management of patients with depression. For example, there have been no head-to-head trials comparing DHEA to standard antidepressants... The risks and benefits of long-term DHEA administration also remain to be further clarified."